Assay Detail
Binding
CHEMBL4402292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat lens ALR2 using L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.10 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.51 |
| CHEMBL4445514 | — | — | 1 | 7.00 |
| CHEMBL3409366 | — | — | 1 | 6.74 |
| CHEMBL3409369 | — | — | 1 | 6.38 |
| CHEMBL4476269 | — | — | 1 | 6.20 |
| CHEMBL4547451 | — | — | 1 | 5.49 |
| CHEMBL4447350 | — | — | 1 | 5.33 |
| CHEMBL4553065 | — | — | 1 | 5.20 |
| CHEMBL4465733 | — | — | 1 | 4.99 |
| CHEMBL4467988 | — | — | 1 | 4.85 |
| CHEMBL4570469 | — | — | 1 | 4.80 |
| CHEMBL4580855 | — | — | 1 | 4.63 |
| CHEMBL4453241 | — | — | 1 | 4.47 |
| CHEMBL4592035 | — | — | 1 | 4.45 |
| CHEMBL4550229 | — | — | 1 | 4.42 |
| CHEMBL4518301 | — | — | 1 | 4.41 |
| CHEMBL4471025 | — | — | 1 | 4.39 |
| CHEMBL4436476 | — | — | 1 | 4.27 |
| CHEMBL4545610 | — | — | 1 | 4.26 |
| CHEMBL4564163 | — | — | 1 | 4.14 |
| CHEMBL4578039 | — | — | 1 | 4.13 |
| CHEMBL4463496 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4445514 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3409366 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3409369 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL4476269 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL4547451 | — | IC50 | = | 3274.0 | nM | 5.49 |
| CHEMBL4447350 | — | IC50 | = | 4636.0 | nM | 5.33 |
| CHEMBL4553065 | — | IC50 | = | 6382.0 | nM | 5.20 |
| CHEMBL4465733 | — | IC50 | = | 10140.0 | nM | 4.99 |
| CHEMBL4467988 | — | IC50 | = | 14260.0 | nM | 4.85 |
| CHEMBL4570469 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL4580855 | — | IC50 | = | 23550.0 | nM | 4.63 |
| CHEMBL4453241 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4592035 | — | IC50 | = | 35170.0 | nM | 4.45 |
| CHEMBL4550229 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL4518301 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL4471025 | — | IC50 | = | 40620.0 | nM | 4.39 |
| CHEMBL4436476 | — | IC50 | = | 53970.0 | nM | 4.27 |
| CHEMBL4545610 | — | IC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL4564163 | — | IC50 | = | 71860.0 | nM | 4.14 |
| CHEMBL4578039 | — | IC50 | = | 74680.0 | nM | 4.13 |
| CHEMBL4463496 | — | IC50 | = | 75190.0 | nM | 4.12 |