Assay Detail
Binding
CHEMBL4402293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat kidney ALR1 using sodium D-glucuronate as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.63 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 5.65 |
| CHEMBL4445514 | — | — | 1 | 5.04 |
| CHEMBL4547451 | — | — | 1 | 4.62 |
| CHEMBL4476269 | — | — | 1 | 4.56 |
| CHEMBL4467988 | — | — | 1 | 4.53 |
| CHEMBL4553065 | — | — | 1 | 4.52 |
| CHEMBL4570469 | — | — | 1 | 4.37 |
| CHEMBL4447350 | — | — | 1 | 4.24 |
| CHEMBL4465733 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 2257.0 | nM | 5.65 |
| CHEMBL4445514 | — | IC50 | = | 9156.0 | nM | 5.04 |
| CHEMBL4547451 | — | IC50 | = | 23890.0 | nM | 4.62 |
| CHEMBL4476269 | — | IC50 | = | 27720.0 | nM | 4.56 |
| CHEMBL4467988 | — | IC50 | = | 29210.0 | nM | 4.53 |
| CHEMBL4553065 | — | IC50 | = | 29890.0 | nM | 4.52 |
| CHEMBL4570469 | — | IC50 | = | 42510.0 | nM | 4.37 |
| CHEMBL4447350 | — | IC50 | = | 57940.0 | nM | 4.24 |
| CHEMBL4465733 | — | IC50 | = | 73620.0 | nM | 4.13 |