Assay Detail
Binding
CHEMBL4402445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH2 domain in IFNalpha/IL23-stimulated human Kit225 cells by luciferase reporter assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.08 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571920 | — | — | 1 | 7.92 |
| CHEMBL4460368 | — | — | 1 | 7.66 |
| CHEMBL4532948 | — | — | 1 | 7.60 |
| CHEMBL4439957 | — | — | 1 | 7.58 |
| CHEMBL4442827 | — | — | 1 | 7.39 |
| CHEMBL4438296 | — | — | 1 | 7.22 |
| CHEMBL4435047 | — | — | 1 | 7.21 |
| CHEMBL4579439 | — | — | 1 | 7.16 |
| CHEMBL4543066 | — | — | 1 | 7.08 |
| CHEMBL4453441 | — | — | 1 | 7.05 |
| CHEMBL4466139 | — | — | 1 | 7.03 |
| CHEMBL4293907 | — | — | 1 | 7.02 |
| CHEMBL4561123 | — | — | 1 | 7.00 |
| CHEMBL4434711 | — | — | 1 | 6.96 |
| CHEMBL4547009 | — | — | 1 | 6.88 |
| CHEMBL4454109 | — | — | 1 | 6.87 |
| CHEMBL4474801 | — | — | 1 | 6.85 |
| CHEMBL4585272 | — | — | 1 | 6.83 |
| CHEMBL4443010 | — | — | 1 | 6.83 |
| CHEMBL4438107 | — | — | 1 | 6.82 |
| CHEMBL4437714 | — | — | 1 | 6.63 |
| CHEMBL4517542 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571920 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4460368 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4532948 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4439957 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4442827 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4438296 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL4435047 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL4579439 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4543066 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL4453441 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL4466139 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL4293907 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL4561123 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL4434711 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL4547009 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL4454109 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL4474801 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4585272 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL4443010 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL4438107 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL4437714 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL4517542 | — | Ki | = | 614.0 | nM | 6.21 |