Assay Detail
Binding
CHEMBL4403237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.46 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1618272 | — | — | 1 | 6.51 |
| CHEMBL4568508 | — | — | 1 | 6.07 |
| CHEMBL4457897 | — | — | 1 | 5.91 |
| CHEMBL4444163 | — | — | 1 | 5.90 |
| CHEMBL4441069 | — | — | 1 | 5.42 |
| CHEMBL4550042 | — | — | 1 | 5.41 |
| CHEMBL4564074 | — | — | 1 | 5.17 |
| CHEMBL4574361 | — | — | 1 | 5.17 |
| CHEMBL4551909 | — | — | 1 | 5.03 |
| CHEMBL4441173 | — | — | 1 | 4.87 |
| CHEMBL4463882 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1618272 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4568508 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4457897 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4444163 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4441069 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4550042 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4564074 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4574361 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL4551909 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL4441173 | — | IC50 | = | 13490.0 | nM | 4.87 |
| CHEMBL4463882 | — | IC50 | = | 24240.0 | nM | 4.62 |