Assay Detail
Binding
CHEMBL4403374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.53 | 9.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297468 | ZETOMIPZOMIB | 2.0 | 1 | 9.88 |
| CHEMBL270515 | DELANZOMIB | 2.0 | 1 | 8.00 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 6.21 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297468 | ZETOMIPZOMIB | IC50 | = | 0.131 | nM | 9.88 |
| CHEMBL270515 | DELANZOMIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 940.0 | nM | 6.03 |