Assay Detail
Binding
CHEMBL4403495
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Inhibition of Schistosoma mansoni DHODH
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Schistosoma mansoni |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL4523950) ↗| Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
Publication
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 6.37 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 4.70 |
| CHEMBL1738786 | — | — | 1 | 4.68 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1738786 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 50000.0 | nM | 4.30 |