Assay Detail
Binding
CHEMBL4403575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AgrC in mid-exponential phase Staphylococcus aureus RN6390B assessed as beta-lactamase activity incubated for 80 mins by spectrophotometric method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-histidine kinase AgrC (CHEMBL4726) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.32 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3289785 | — | — | 1 | 8.54 |
| CHEMBL4518791 | — | — | 1 | 8.10 |
| CHEMBL4554516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3289785 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4518791 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4554516 | — | IC50 | < | 1.0 | nM | - |