Assay Detail
Binding
CHEMBL4403585
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Inhibition of AgrC-2 in Staphylococcus aureus RN9372 incubated for 60 to 90 mins in presence of AIP agonist by beta-lactamase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.86 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442959 | — | — | 1 | 8.40 |
| CHEMBL4566585 | — | — | 1 | 8.22 |
| CHEMBL4438789 | — | — | 1 | 7.66 |
| CHEMBL2337554 | — | — | 1 | 7.60 |
| CHEMBL4559145 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442959 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4566585 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4438789 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2337554 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4559145 | — | IC50 | = | 40.0 | nM | 7.40 |