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Compound Detail

CHEMBL4559145

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CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@@H]32)[C@@H](C)O)CSC(=O)[C@H](CCSC)NC1=O

Basic Information

ChEMBL ID CHEMBL4559145
Phase Preclinical
Structure Type MOL
InChI Key IVSQPZQYDSKQRW-QWAJSINJSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1187.4
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C53H74N10O15S3
MW 1187.43

Activity Summary

IC50 1 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 7.4 7.4 40.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 40.0 nM 7.4 Inhibition of AgrC-2 in Staphylococcus aureus RN9372 incubated for 60 to 90 mins... 31658413

Literature References

PubMed DOI Target Context # Activities
31658413 10.1021/acs.jmedchem.9b00798 Unchecked 1

Data from ChEMBL 36 via Core Engine