Assay Detail
Binding
CHEMBL4404061
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Agonist activity at Aliivibrio fischeri LuxR by luminescence method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aliivibrio fischeri |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LuxR (CHEMBL5351) ↗| Type | SINGLE PROTEIN |
| Organism | Aliivibrio fischeri |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.29 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517457 | — | — | 1 | 6.60 |
| CHEMBL4535946 | — | — | 1 | 6.30 |
| CHEMBL4579576 | — | — | 1 | 5.96 |
| CHEMBL15908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517457 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4535946 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4579576 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL15908 | — | EC50 | > | 6000.0 | nM | - |