Assay Detail
Binding
CHEMBL4404064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Aliivibrio fischeri ES114 LuxR after 4 to 8 hrs by luminescence method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aliivibrio fischeri ES114 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LuxR (CHEMBL5351) ↗| Type | SINGLE PROTEIN |
| Organism | Aliivibrio fischeri |
Publication
Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468624 | — | — | 1 | 6.22 |
| CHEMBL468790 | — | — | 1 | 6.05 |
| CHEMBL468791 | — | — | 1 | 6.00 |
| CHEMBL259441 | — | — | 1 | 5.96 |
| CHEMBL584972 | — | — | 1 | 5.85 |
| CHEMBL575294 | — | — | 1 | 5.43 |
| CHEMBL4571277 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468624 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL468790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL468791 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL259441 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL584972 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL575294 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4571277 | — | IC50 | = | 4100.0 | nM | 5.39 |