Assay Detail
Binding
CHEMBL4404287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocytes by measuring hemoglobin release incubated for 15 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit (CHEMBL1932910) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain NCTC 8325) |
Publication
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.26 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446834 | — | — | 1 | 5.85 |
| CHEMBL4540126 | — | — | 1 | 5.58 |
| CHEMBL4536802 | — | — | 1 | 5.48 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 5.44 |
| CHEMBL4438765 | — | — | 1 | 5.02 |
| CHEMBL4457363 | — | — | 1 | 4.83 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446834 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4540126 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4536802 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2141296 | IXAZOMIB | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4438765 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4457363 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL325041 | BORTEZOMIB | EC50 | = | 23500.0 | nM | 4.63 |