Assay Detail
Binding
CHEMBL4404292
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Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) assessed as shifting of melting peak of SaClpP by differential scanning calorimetry analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit (CHEMBL1932910) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain NCTC 8325) |
Publication
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.30 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446834 | — | — | 1 | 5.90 |
| CHEMBL1813256 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446834 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL1813256 | — | EC50 | = | 19900.0 | nM | 4.70 |