Assay Detail
Functional
CHEMBL4404500
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Antiviral activity against Human coronavirus 229E infected in HuH7 cells expressing T7 RNA polymerase assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by Alamar blue based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.68 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590737 | — | — | 1 | 6.22 |
| CHEMBL4442435 | — | — | 1 | 5.89 |
| CHEMBL4441971 | — | — | 1 | 5.75 |
| CHEMBL4438019 | — | — | 1 | 5.60 |
| CHEMBL3780681 | — | — | 1 | 4.93 |
| CHEMBL4542462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590737 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4442435 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4441971 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4438019 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3780681 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4542462 | — | EC50 | - | — | - |