Assay Detail
Functional
CHEMBL4404501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Middle East respiratory syndrome coronavirus infected in HuH7 cells expressing T7 RNA polymerase assessed as reduction in virus-induced cytopathic effect incubated for 2 days by non-radioactive cell proliferation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗| Type | ORGANISM |
| Organism | Middle East respiratory syndrome-related coronavirus |
Publication
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.17 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441971 | — | — | 1 | 9.40 |
| CHEMBL4590737 | — | — | 1 | 8.34 |
| CHEMBL3780681 | — | — | 1 | 8.32 |
| CHEMBL4438019 | — | — | 1 | 8.15 |
| CHEMBL4542462 | — | — | 1 | 7.70 |
| CHEMBL4442435 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441971 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4590737 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3780681 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4438019 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4542462 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4442435 | — | EC50 | = | 80.0 | nM | 7.10 |