Assay Detail
Functional
CHEMBL4404540
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Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry after 48 hrs by GFP reporter gene based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human adenovirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.67 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448375 | — | — | 1 | 6.58 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.91 |
| CHEMBL4436153 | — | — | 1 | 5.86 |
| CHEMBL4553793 | — | — | 1 | 5.80 |
| CHEMBL2313077 | — | — | 1 | 5.78 |
| CHEMBL4474737 | — | — | 1 | 5.65 |
| CHEMBL4460349 | — | — | 1 | 5.60 |
| CHEMBL2088010 | — | — | 1 | 5.57 |
| CHEMBL4531551 | — | — | 1 | 5.01 |
| CHEMBL4439945 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448375 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4436153 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4553793 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL2313077 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4474737 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4460349 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2088010 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4531551 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4439945 | — | IC50 | = | 11200.0 | nM | 4.95 |