Assay Detail
Binding
CHEMBL4404753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant KAT6A (unknown origin) expressed in C57BL/6 mouse embryonic fibroblasts assessed as reduction in cell proliferation supplemented with fresh medium containing compounds every 48 hrs after for 168 hrs under low oxygen condition
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.13 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451170 | — | — | 1 | 6.32 |
| CHEMBL4455897 | — | — | 1 | 6.26 |
| CHEMBL4461380 | — | — | 1 | 6.21 |
| CHEMBL4449359 | — | — | 1 | 6.20 |
| CHEMBL4445093 | — | — | 1 | 6.19 |
| CHEMBL4464911 | — | — | 1 | 6.00 |
| CHEMBL4446917 | — | — | 1 | 5.93 |
| CHEMBL4566403 | — | — | 1 | 5.90 |
| CHEMBL4513522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451170 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4455897 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL4461380 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4449359 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4445093 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4464911 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4446917 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4566403 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4513522 | — | IC50 | > | 10000.0 | nM | - |