Use UniProt Q92794 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL3774298 Target Snapshot
Histone acetyltransferase KAT6A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q92794. Use UniProt Q92794 as the stable identity anchor, then attach disease evidence before program review.
Histone acetyltransferase KAT6A
Review this target as Histone acetyltransferase KAT6A, mapped to UniProt Q92794. Sequence length is 2004 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Histone acetyltransferase KAT6A as ChEMBL target CHEMBL3774298, mapped to UniProt Q92794. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Histone acetyltransferase KAT6A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92794 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone acetyltransferase KAT6A |
| UniProt Accession | Q92794 |
| Component Type | Protein |
| Sequence Length | 2004 aa |
Histone acetyltransferase KAT6A
How to read this target
Review this target as Histone acetyltransferase KAT6A, mapped to UniProt Q92794. Sequence length is 2004 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5723326 | 9.57 | Ki | 0.27 | Preclinical |
| CHEMBL6000330 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL5792567 | 9.49 | Ki | 0.32 | Preclinical |
| CHEMBL5940985 | 9.48 | Ki | 0.33 | Preclinical |
| CHEMBL5927368 | 9.47 | Ki | 0.34 | Preclinical |
| CHEMBL5993180 | 9.46 | Ki | 0.35 | Preclinical |
| CHEMBL6063716 | 9.44 | Ki | 0.36 | Preclinical |
| CHEMBL5886450 | 9.42 | Ki | 0.38 | Preclinical |
| CHEMBL5853409 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL5852195 | 9.37 | Ki | 0.43 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 27 assays, 553 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 21 | 297 | 6.6 |
| cell-based format | 5 | 248 | 6.4 |
| assay format | 1 | 8 | 6.1 |
Functional — 3 assays, 3 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 8.7 |
| cell-based format | 1 | 1 | 6.6 |