Compound Detail
CHEMBL5723326
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Basic Information
| ChEMBL ID | CHEMBL5723326 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VNSQFPFWUAZOTQ-UHFFFAOYSA-N |
5
Targets
29
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names
Molecular Properties
444.5
MW (Da)
2.90
ALogP
9
HBA
1
HBD
117.7
PSA (Ų)
0.44
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 29 meas. best 9.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase KAT6A CHEMBL3774298 | Ki | 9.57 | 9.2667 | 0.3 | 9 |
| Histone acetyltransferase KAT6B CHEMBL3774300 | Ki | 9.38 | 8.8513 | 0.4 | 8 |
| Histone acetyltransferase KAT7 CHEMBL3774299 | Ki | 7.4 | 7.285 | 40.0 | 4 |
| Histone acetyltransferase KAT5 CHEMBL5750 | Ki | 6.43 | 6.2725 | 370.0 | 4 |
| Histone acetyltransferase KAT8 CHEMBL1932912 | Ki | 6.3 | 6.1775 | 500.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5724709 | HEK-293T | 2 |
| - | 10.6019/CHEMBL5724709 | U2OS | 2 |
| - | 10.6019/CHEMBL5724709 | Fibroblast | 2 |
| - | 10.6019/CHEMBL5723035 | Histone acetyltransferase KAT6A | 1 |
| - | 10.6019/CHEMBL5723035 | Histone acetyltransferase KAT6B | 1 |
| - | 10.6019/CHEMBL5724796 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5724796 | Cyclin-dependent kinase 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5724796 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5724796 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5724796 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5724796 | Fibroblast growth factor receptor 2 | 1 |
| - | 10.6019/CHEMBL5724796 | Peregrin | 1 |
| - | 10.6019/CHEMBL5724796 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5724796 | Bromodomain-containing protein 4 | 1 |
Data from ChEMBL 36 via Core Engine