Assay Detail
Binding
CHEMBL4406334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1 hr in presence of DPPS and PI5P by ADP-Glo assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (CHEMBL5667) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.86 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436648 | — | — | 1 | 5.77 |
| CHEMBL4447308 | — | — | 1 | 5.72 |
| CHEMBL4454033 | — | — | 1 | 5.57 |
| CHEMBL4519752 | — | — | 1 | 5.37 |
| CHEMBL4577337 | — | — | 1 | 5.07 |
| CHEMBL4455633 | — | — | 1 | 5.03 |
| CHEMBL4467678 | — | — | 1 | 4.82 |
| CHEMBL4456203 | — | — | 1 | 4.66 |
| CHEMBL4573568 | — | — | 1 | 4.60 |
| CHEMBL4436057 | — | — | 1 | 4.60 |
| CHEMBL4475338 | — | — | 1 | 4.58 |
| CHEMBL4559878 | — | — | 1 | 4.57 |
| CHEMBL4441998 | — | — | 1 | 4.55 |
| CHEMBL4440465 | — | — | 1 | 4.54 |
| CHEMBL4567681 | — | — | 1 | 4.44 |
| CHEMBL4449110 | — | — | 1 | 4.37 |
| CHEMBL4454398 | — | — | 1 | 4.35 |
| CHEMBL4527801 | — | — | 1 | - |
| CHEMBL4459957 | — | — | 1 | - |
| CHEMBL4538609 | — | — | 1 | - |
| CHEMBL4443959 | — | — | 1 | - |
| CHEMBL4458985 | — | — | 1 | - |
| CHEMBL4436523 | — | — | 1 | - |
| CHEMBL4540008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436648 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4447308 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4454033 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4519752 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4577337 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4455633 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4467678 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4456203 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4573568 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4436057 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4475338 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4559878 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4441998 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4440465 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4567681 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4449110 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4454398 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4527801 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4459957 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4538609 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4443959 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4458985 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4436523 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4540008 | — | IC50 | > | 50000.0 | nM | - |