Compound Detail
CHEMBL4441998
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Basic Information
| ChEMBL ID | CHEMBL4441998 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KYVDESWKZLGEKQ-MLPAPPSSSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
299.3
MW (Da)
3.03
ALogP
4
HBA
2
HBD
65.8
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta CHEMBL5667 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | IC50 | = | 28000.0 | nM | 4.55 | Inhibition of GST-tagged recombinant PI5P4Kbeta (unknown origin) incubated for 1... | 32298120 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32298120 | 10.1021/acs.jmedchem.0c00227 | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 1 |
| 32298120 | 10.1021/acs.jmedchem.0c00227 | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 1 |
| 32298120 | 10.1021/acs.jmedchem.0c00227 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine