Assay Detail
Binding
CHEMBL4406418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.23 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564920 | — | — | 1 | 7.00 |
| CHEMBL4557940 | — | — | 1 | 6.70 |
| CHEMBL4590991 | — | — | 1 | 6.70 |
| CHEMBL4435658 | — | — | 1 | 6.52 |
| CHEMBL4447108 | — | — | 1 | 6.40 |
| CHEMBL4466562 | — | — | 1 | 6.30 |
| CHEMBL4568702 | — | — | 1 | 6.16 |
| CHEMBL4554028 | — | — | 1 | 5.85 |
| CHEMBL4442292 | — | — | 1 | 5.77 |
| CHEMBL101168 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564920 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4557940 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4590991 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4435658 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4447108 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4466562 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4568702 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4554028 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4442292 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL101168 | — | IC50 | = | 12000.0 | nM | 4.92 |