Assay Detail
ADMET
CHEMBL4406530
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Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.01 | 8.33 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.33 |
| CHEMBL2203406 | — | — | 1 | 7.68 |
| CHEMBL1700053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2203406 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1700053 | — | IC50 | > | 100000.0 | nM | - |