Assay Detail
ADMET
CHEMBL4406630
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Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.11 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203406 | — | — | 1 | 6.65 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 5.57 |
| CHEMBL4476784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203406 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL301265 | PRAMIPEXOLE | Ki | = | 2683.0 | nM | 5.57 |
| CHEMBL4476784 | — | Ki | - | — | - |