Assay Detail
Functional
CHEMBL4406715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI infected in human MT2 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.65 | 10.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592624 | — | — | 1 | 10.07 |
| CHEMBL4568050 | — | — | 1 | 9.52 |
| CHEMBL4460799 | — | — | 1 | 9.40 |
| CHEMBL4532946 | — | — | 1 | 9.34 |
| CHEMBL4449179 | — | — | 1 | 8.89 |
| CHEMBL4435411 | — | — | 1 | 8.76 |
| CHEMBL4437746 | — | — | 1 | 8.73 |
| CHEMBL4586218 | — | — | 1 | 8.65 |
| CHEMBL4533315 | — | — | 1 | 8.57 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.49 |
| CHEMBL4514504 | — | — | 1 | 8.48 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.68 |
| CHEMBL4545005 | — | — | 1 | 7.42 |
| CHEMBL4469549 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592624 | — | IC50 | = | 0.086 | nM | 10.07 |
| CHEMBL4568050 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4460799 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4532946 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4449179 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL4435411 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL4437746 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL4586218 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL4533315 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4514504 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4545005 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4469549 | — | IC50 | = | 71.7 | nM | 7.14 |