Assay Detail
Binding
CHEMBL4406785
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Inhibition of ALK2 G328V mutant (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.96 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548795 | — | — | 1 | 8.52 |
| CHEMBL4440168 | — | — | 1 | 8.40 |
| CHEMBL4553210 | — | — | 1 | 8.30 |
| CHEMBL4575655 | — | — | 1 | 7.80 |
| CHEMBL4575999 | — | — | 1 | 6.77 |
| CHEMBL4434694 | — | — | 1 | - |
| CHEMBL4435320 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548795 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4440168 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4553210 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4575655 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4575999 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4434694 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL4435320 | — | IC50 | < | 2.0 | nM | - |