Assay Detail
Binding
CHEMBL4406786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435320 | — | — | 1 | 8.40 |
| CHEMBL4434694 | — | — | 1 | 8.30 |
| CHEMBL4548795 | — | — | 1 | 8.22 |
| CHEMBL4440168 | — | — | 1 | 8.10 |
| CHEMBL4553210 | — | — | 1 | 8.05 |
| CHEMBL4575655 | — | — | 1 | 7.72 |
| CHEMBL4575999 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435320 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4434694 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4548795 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4440168 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4553210 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4575655 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4575999 | — | IC50 | = | 226.0 | nM | 6.65 |