Assay Detail
Binding
CHEMBL4407172
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Inhibition of MMP9 (unknown origin) using QF-24 as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for 1 hr by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.17 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.51 |
| CHEMBL2103847 | TOSEDOSTAT | 2.0 | 1 | 5.82 |
| CHEMBL4448936 | — | — | 1 | - |
| CHEMBL4460082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2103847 | TOSEDOSTAT | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4448936 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4460082 | — | IC50 | > | 100000.0 | nM | - |