Assay Detail
Functional
CHEMBL4407342
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Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 5.59 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457064 | — | — | 1 | 6.68 |
| CHEMBL4591854 | — | — | 1 | 6.55 |
| CHEMBL4445510 | — | — | 1 | 6.55 |
| CHEMBL4517950 | — | — | 1 | 6.47 |
| CHEMBL4441825 | — | — | 1 | 6.44 |
| CHEMBL4585120 | — | — | 1 | 6.41 |
| CHEMBL4447158 | — | — | 1 | 6.37 |
| CHEMBL4475923 | — | — | 1 | 6.35 |
| CHEMBL4568343 | — | — | 1 | 6.33 |
| CHEMBL4451765 | — | — | 1 | 6.29 |
| CHEMBL4519793 | — | — | 1 | 6.25 |
| CHEMBL4438877 | — | — | 1 | 6.19 |
| CHEMBL4554668 | — | — | 1 | 6.17 |
| CHEMBL4531735 | — | — | 1 | 6.16 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 6.14 |
| CHEMBL4589576 | — | — | 1 | 6.13 |
| CHEMBL4449509 | — | — | 1 | 6.11 |
| CHEMBL4567295 | — | — | 1 | 6.10 |
| CHEMBL4460525 | — | — | 1 | 6.04 |
| CHEMBL4441416 | — | — | 1 | 6.04 |
| CHEMBL4529738 | — | — | 1 | 6.00 |
| CHEMBL4524940 | — | — | 1 | 5.99 |
| CHEMBL4467439 | — | — | 1 | 5.99 |
| CHEMBL4435138 | — | — | 1 | 5.98 |
| CHEMBL4470606 | — | — | 1 | 5.96 |
| CHEMBL4533641 | — | — | 1 | 5.96 |
| CHEMBL4440965 | — | — | 1 | 5.96 |
| CHEMBL4450403 | — | — | 1 | 5.81 |
| CHEMBL4518386 | — | — | 1 | 5.81 |
| CHEMBL4590906 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457064 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4591854 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4445510 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4517950 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4441825 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4585120 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4447158 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4475923 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4568343 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4451765 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4519793 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4438877 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4554668 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4531735 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4589576 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4449509 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4567295 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4460525 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4441416 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4529738 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4524940 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4467439 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4435138 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4440965 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4533641 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4470606 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4450403 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4518386 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4590906 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4453662 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4554683 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4546392 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4465905 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4543839 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL4450141 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL4582476 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4457188 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4460756 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4578995 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4447967 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4470602 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4522719 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL4544069 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL4593086 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL4446884 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL4560290 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL4530506 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL4588742 | — | IC50 | = | 8700.0 | nM | 5.06 |