Assay Detail
Functional
CHEMBL4407363
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Antiproliferative activity against human LNCAP cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.76 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554668 | — | — | 1 | 7.40 |
| CHEMBL4475923 | — | — | 1 | 7.40 |
| CHEMBL4441416 | — | — | 1 | 7.30 |
| CHEMBL4440965 | — | — | 1 | 7.30 |
| CHEMBL4457064 | — | — | 1 | 7.22 |
| CHEMBL4519793 | — | — | 1 | 7.22 |
| CHEMBL4441825 | — | — | 1 | 7.22 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 7.16 |
| CHEMBL4470606 | — | — | 1 | 7.16 |
| CHEMBL4447158 | — | — | 1 | 7.10 |
| CHEMBL4567295 | — | — | 1 | 7.00 |
| CHEMBL4445510 | — | — | 1 | 7.00 |
| CHEMBL4460525 | — | — | 1 | 6.89 |
| CHEMBL4449509 | — | — | 1 | 6.80 |
| CHEMBL4517950 | — | — | 1 | 6.80 |
| CHEMBL4438877 | — | — | 1 | 6.80 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 6.75 |
| CHEMBL4589576 | — | — | 1 | 6.72 |
| CHEMBL4451765 | — | — | 1 | 6.68 |
| CHEMBL4568343 | — | — | 1 | 6.60 |
| CHEMBL4450403 | — | — | 1 | 6.39 |
| CHEMBL4447967 | — | — | 1 | 6.19 |
| CHEMBL4593086 | — | — | 1 | 6.18 |
| CHEMBL4518523 | — | — | 1 | 5.94 |
| CHEMBL4524940 | — | — | 1 | 5.75 |
| CHEMBL4546392 | — | — | 1 | 5.72 |
| CHEMBL4590906 | — | — | 1 | 5.71 |
| CHEMBL4467439 | — | — | 1 | - |
| CHEMBL4531735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554668 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4475923 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4441416 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4440965 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4457064 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4519793 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4441825 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4470606 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4447158 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4567295 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4445510 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4460525 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4449509 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4517950 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4438877 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2325741 | CAPIVASERTIB | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4589576 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4451765 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4568343 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4450403 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4447967 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4593086 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4518523 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4524940 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4546392 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4590906 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4467439 | — | IC50 | - | — | - | |
| CHEMBL4531735 | — | IC50 | - | — | - |