Assay Detail
Binding
CHEMBL4407553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal His-tagged Pseudomonas aeruginosa PAO1 biotin carboxylase expressed in Escherichia coli Rosetta(DE3) pLysS cells using biotin as substrate by spectroscopic analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa PAO1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Biotin carboxylase (CHEMBL4523221) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Publication
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.94 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466052 | — | — | 1 | 7.50 |
| CHEMBL4518489 | — | — | 1 | 7.48 |
| CHEMBL4530311 | — | — | 1 | 7.44 |
| CHEMBL4459017 | — | — | 1 | 7.19 |
| CHEMBL4450292 | — | — | 1 | 7.10 |
| CHEMBL4563086 | — | — | 1 | 7.08 |
| CHEMBL4445287 | — | — | 1 | 7.03 |
| CHEMBL4551132 | — | — | 1 | 6.89 |
| CHEMBL4564355 | — | — | 1 | 6.85 |
| CHEMBL4582507 | — | — | 1 | 6.77 |
| CHEMBL57531 | — | — | 1 | 6.75 |
| CHEMBL4440951 | — | — | 1 | 6.72 |
| CHEMBL4464608 | — | — | 1 | 6.50 |
| CHEMBL58627 | — | — | 1 | 6.50 |
| CHEMBL4520904 | — | — | 1 | 6.36 |
| CHEMBL4453148 | — | — | 1 | - |
| CHEMBL4519530 | — | — | 1 | - |
| CHEMBL4470362 | — | — | 1 | - |
| CHEMBL4476532 | — | — | 1 | - |
| CHEMBL4546703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466052 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4518489 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4530311 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4459017 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4450292 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4563086 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4445287 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4551132 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4564355 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4582507 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL57531 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4440951 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4464608 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL58627 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4520904 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4453148 | — | IC50 | <= | 15.0 | nM | - |
| CHEMBL4519530 | — | IC50 | <= | 15.0 | nM | - |
| CHEMBL4470362 | — | IC50 | <= | 15.0 | nM | - |
| CHEMBL4476532 | — | IC50 | <= | 15.0 | nM | - |
| CHEMBL4546703 | — | IC50 | <= | 15.0 | nM | - |