Assay Detail
Binding
CHEMBL4407783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE3) using Bz-nKRR-AMC as substrate preincubated for 15 mins followed by substrate addition and measured by fluorescence based assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zika virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cell-active carbazole derivatives as inhibitors of the zika virus protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.29 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448497 | — | — | 1 | 6.28 |
| CHEMBL4558642 | — | — | 1 | 6.09 |
| CHEMBL4568823 | — | — | 1 | 6.00 |
| CHEMBL4437288 | — | — | 1 | 5.77 |
| CHEMBL4446364 | — | — | 1 | 5.76 |
| CHEMBL4447165 | — | — | 1 | 5.72 |
| CHEMBL4518903 | — | — | 1 | 5.46 |
| CHEMBL4532866 | — | — | 1 | 5.39 |
| CHEMBL4548788 | — | — | 1 | 5.09 |
| CHEMBL4457232 | — | — | 1 | 5.04 |
| CHEMBL4470866 | — | — | 1 | 4.86 |
| CHEMBL4437316 | — | — | 1 | 4.85 |
| CHEMBL4535925 | — | — | 1 | 4.83 |
| CHEMBL4444928 | — | — | 1 | 4.59 |
| CHEMBL4544053 | — | — | 1 | 4.49 |
| CHEMBL3040170 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448497 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4558642 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4568823 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4437288 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4446364 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4447165 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4518903 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4532866 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL4548788 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4457232 | — | IC50 | = | 9190.0 | nM | 5.04 |
| CHEMBL4470866 | — | IC50 | = | 13860.0 | nM | 4.86 |
| CHEMBL4437316 | — | IC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL4535925 | — | IC50 | = | 14940.0 | nM | 4.83 |
| CHEMBL4444928 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL4544053 | — | IC50 | = | 32520.0 | nM | 4.49 |
| CHEMBL3040170 | — | IC50 | = | 38275.0 | nM | 4.42 |