Assay Detail
Binding
CHEMBL4407816
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Inhibition of recombinant Plasmodium falciparum IspC expressed in Escherichia coli using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (CHEMBL4295619) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.48 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4567904 | — | — | 1 | 7.96 |
| CHEMBL4590343 | — | — | 1 | 7.89 |
| CHEMBL4592986 | — | — | 1 | 7.70 |
| CHEMBL4544750 | — | — | 1 | 7.62 |
| CHEMBL4474216 | — | — | 1 | 7.54 |
| CHEMBL4447571 | — | — | 1 | 7.50 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 6.80 |
| CHEMBL4437978 | — | — | 1 | 6.66 |
| CHEMBL4564404 | — | — | 1 | 6.00 |
| CHEMBL4458458 | — | — | 1 | 5.43 |
| CHEMBL4462089 | — | — | 1 | 5.26 |
| CHEMBL4452553 | — | — | 1 | 5.12 |
| CHEMBL4545211 | — | — | 1 | 5.07 |
| CHEMBL4578312 | — | — | 1 | 4.19 |
| CHEMBL4572338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4567904 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4590343 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4592986 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4544750 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4474216 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4447571 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4437978 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4564404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4458458 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4462089 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4452553 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4545211 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4578312 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4572338 | — | IC50 | = | 823000.0 | nM | - |