Assay Detail
Binding
CHEMBL4407818
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Inhibition of recombinant Mycobacterium tuberculosis IspC expressed in Escherichia coli M15 using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL5630) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.66 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474216 | — | — | 1 | 7.00 |
| CHEMBL4590343 | — | — | 1 | 6.96 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 6.64 |
| CHEMBL4567904 | — | — | 1 | 6.50 |
| CHEMBL4592986 | — | — | 1 | 5.36 |
| CHEMBL4447571 | — | — | 1 | 5.09 |
| CHEMBL4564404 | — | — | 1 | 4.68 |
| CHEMBL4544750 | — | — | 1 | 4.36 |
| CHEMBL4462089 | — | — | 1 | 4.36 |
| CHEMBL4452553 | — | — | 1 | - |
| CHEMBL4545211 | — | — | 1 | - |
| CHEMBL4572338 | — | — | 1 | - |
| CHEMBL4458458 | — | — | 1 | - |
| CHEMBL4578312 | — | — | 1 | - |
| CHEMBL4437978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474216 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4590343 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4567904 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4592986 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4447571 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4564404 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4544750 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4462089 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4452553 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL4545211 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL4572338 | — | IC50 | = | 621000.0 | nM | - |
| CHEMBL4458458 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4578312 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL4437978 | — | IC50 | = | 194000.0 | nM | - |