Assay Detail
Functional
CHEMBL4408283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.81 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447541 | — | — | 1 | 9.60 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.00 |
| CHEMBL4464909 | — | — | 1 | 8.82 |
| CHEMBL4440494 | — | — | 1 | 8.68 |
| CHEMBL4526719 | — | — | 1 | 8.64 |
| CHEMBL4473254 | — | — | 1 | 8.49 |
| CHEMBL4524533 | — | — | 1 | 8.36 |
| CHEMBL4522990 | — | — | 1 | 8.29 |
| CHEMBL4436465 | — | — | 1 | 8.03 |
| CHEMBL4442113 | — | — | 1 | 7.92 |
| CHEMBL4451991 | — | — | 1 | 7.77 |
| CHEMBL4554434 | — | — | 1 | 7.75 |
| CHEMBL4525021 | — | — | 1 | 7.63 |
| CHEMBL4449830 | — | — | 1 | 7.53 |
| CHEMBL4551856 | — | — | 1 | 7.51 |
| CHEMBL4541938 | — | — | 1 | 7.50 |
| CHEMBL4533893 | — | — | 1 | 7.39 |
| CHEMBL4459196 | — | — | 1 | 7.29 |
| CHEMBL4521561 | — | — | 1 | 6.79 |
| CHEMBL4569888 | — | — | 1 | 6.75 |
| CHEMBL4537302 | — | — | 1 | 6.26 |
| CHEMBL4546434 | — | — | 1 | 5.76 |
| CHEMBL4453762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447541 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4464909 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4440494 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4526719 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4473254 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4524533 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4522990 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4436465 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4442113 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL4451991 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4554434 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4525021 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL4449830 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL4551856 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4541938 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL4533893 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL4459196 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL4521561 | — | IC50 | = | 160.2 | nM | 6.79 |
| CHEMBL4569888 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4537302 | — | IC50 | = | 553.0 | nM | 6.26 |
| CHEMBL4546434 | — | IC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL4453762 | — | IC50 | > | 10000.0 | nM | - |