Assay Detail
Binding
CHEMBL4408359
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Inhibition of recombinant human MMP9 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every min for 20 mins by colorimetric assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.91 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.48 |
| CHEMBL311932 | — | — | 1 | 8.06 |
| CHEMBL4580198 | — | — | 1 | 6.18 |
| CHEMBL4574404 | — | — | 1 | 5.89 |
| CHEMBL4469402 | — | — | 1 | 5.77 |
| CHEMBL4558237 | — | — | 1 | 5.68 |
| CHEMBL4573985 | — | — | 1 | 5.51 |
| CHEMBL4586740 | — | — | 1 | 5.50 |
| CHEMBL4483313 | — | — | 1 | 5.46 |
| CHEMBL4471187 | — | — | 1 | 5.44 |
| CHEMBL4435530 | — | — | 1 | 5.29 |
| CHEMBL4441474 | — | — | 1 | 5.28 |
| CHEMBL4581930 | — | — | 1 | 5.22 |
| CHEMBL1650637 | — | — | 1 | 4.96 |
| CHEMBL4580239 | — | — | 1 | - |
| CHEMBL4462392 | — | — | 1 | - |
| CHEMBL4461678 | — | — | 1 | - |
| CHEMBL4462525 | — | — | 1 | - |
| CHEMBL4474368 | — | — | 1 | - |
| CHEMBL4589959 | — | — | 1 | - |
| CHEMBL4438218 | — | — | 1 | - |
| CHEMBL4545865 | — | — | 1 | - |
| CHEMBL4527922 | — | — | 1 | - |
| CHEMBL4450703 | — | — | 1 | - |
| CHEMBL4547811 | — | — | 1 | - |
| CHEMBL4437450 | — | — | 1 | - |
| CHEMBL4455328 | — | — | 1 | - |
| CHEMBL4458022 | — | — | 1 | - |
| CHEMBL4555080 | — | — | 1 | - |
| CHEMBL4463413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL311932 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4580198 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4574404 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4469402 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4558237 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4573985 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4586740 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4483313 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4471187 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4435530 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4441474 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4581930 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1650637 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4562840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4526272 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442166 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4529344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580239 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4462392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4461678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4462525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4474368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4589959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438218 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4545865 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4527922 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4450703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4437450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4458022 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4463413 | — | IC50 | > | 10000.0 | nM | - |