Assay Detail
Binding
CHEMBL4408558
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Inhibition of N-terminal His-tagged human TDO expressed in Escherichia coli expression system
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.49 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472697 | — | — | 1 | 5.59 |
| CHEMBL4436582 | — | — | 1 | 5.48 |
| CHEMBL4514196 | — | — | 1 | 5.40 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472697 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4436582 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4514196 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | > | 10000.0 | nM | - |