Assay Detail
Binding
CHEMBL4408796
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Competitive irreversible inhibition of CDK9/cyclin T (unknown origin) in presence of Km ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.10 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436535 | — | — | 1 | 6.65 |
| CHEMBL4441405 | — | — | 1 | 6.20 |
| CHEMBL4163879 | — | — | 1 | 6.08 |
| CHEMBL4582951 | — | — | 1 | 6.04 |
| CHEMBL3603847 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436535 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4441405 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL4163879 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL4582951 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL3603847 | — | IC50 | = | 2831.0 | nM | 5.55 |