Assay Detail
Binding
CHEMBL4409077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in mouse brain membranes using [14C]-AEA as substrate incubated for 15 mins by scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.96 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471658 | — | — | 1 | 9.05 |
| CHEMBL4565200 | — | — | 1 | 7.58 |
| CHEMBL4473519 | — | — | 1 | 7.24 |
| CHEMBL4540218 | — | — | 1 | 7.21 |
| CHEMBL4554053 | — | — | 1 | 7.03 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 6.96 |
| CHEMBL4520982 | — | — | 1 | 6.76 |
| CHEMBL4449756 | — | — | 1 | 6.71 |
| CHEMBL4520184 | — | — | 1 | 6.12 |
| CHEMBL4517296 | — | — | 1 | 6.10 |
| CHEMBL4446507 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471658 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL4565200 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4473519 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4540218 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4554053 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL184238 | URB-597 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4520982 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4449756 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4520184 | — | IC50 | = | 757.0 | nM | 6.12 |
| CHEMBL4517296 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL4446507 | — | IC50 | = | 1600.0 | nM | 5.80 |