Assay Detail
Binding
CHEMBL4409078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in mouse brain membranes assessed as inhibitory constant using [14C]-AEA as substrate incubated for 15 mins by scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.54 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471658 | — | — | 1 | 9.64 |
| CHEMBL4565200 | — | — | 1 | 8.16 |
| CHEMBL4473519 | — | — | 1 | 7.80 |
| CHEMBL4540218 | — | — | 1 | 7.80 |
| CHEMBL4554053 | — | — | 1 | 7.60 |
| CHEMBL4520982 | — | — | 1 | 7.34 |
| CHEMBL4449756 | — | — | 1 | 7.30 |
| CHEMBL4520184 | — | — | 1 | 6.71 |
| CHEMBL4517296 | — | — | 1 | 6.69 |
| CHEMBL4446507 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471658 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4565200 | — | Ki | = | 6.88 | nM | 8.16 |
| CHEMBL4473519 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4540218 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4554053 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4520982 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL4449756 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4520184 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL4517296 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL4446507 | — | Ki | = | 420.0 | nM | 6.38 |