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Assay Detail

CHEMBL4409089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human U373MG cells assessed as cell viability incubated for 24 hrs by neutral red uptake based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type U-373MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

U373 MG (CHEMBL615024)
Type CELL-LINE
Organism Homo sapiens

Publication

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.
Grillo A, Chemi G, Brogi S, Brindisi M, Relitti N, Fezza F, Fazio D, Castelletti L, Perdona E, Wong A, Lamponi S, Pecorelli A, Benedusi M, Fantacci M, Valoti M, Valacchi G, Micheli F, Novellino E, Campiani G, Butini S, Maccarrone M, Gemma S.
Eur J Med Chem (2019) 183 : 111674 -111674
PubMed 31518969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.47 4.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4471658 1 4.64
CHEMBL2165084 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4471658 IC50 = 23000.0 nM 4.64
CHEMBL2165084 IC50 = 50000.0 nM 4.30