Assay Detail
Binding
CHEMBL4409380
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Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 10 mins followed by substrate addition measured at first 2 mins by spectrophotometric analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.74 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078685 | TOPIROXOSTAT | 2.0 | 1 | 7.68 |
| CHEMBL4453043 | — | — | 1 | 7.51 |
| CHEMBL4455392 | — | — | 1 | 7.36 |
| CHEMBL4540231 | — | — | 1 | 7.30 |
| CHEMBL4444577 | — | — | 1 | 7.28 |
| CHEMBL4435696 | — | — | 1 | 7.17 |
| CHEMBL4438449 | — | — | 1 | 7.04 |
| CHEMBL4472263 | — | — | 1 | 7.03 |
| CHEMBL4444217 | — | — | 1 | 7.00 |
| CHEMBL4457729 | — | — | 1 | 6.96 |
| CHEMBL4530455 | — | — | 1 | 6.93 |
| CHEMBL4483545 | — | — | 1 | 6.89 |
| CHEMBL4522159 | — | — | 1 | 6.88 |
| CHEMBL4568537 | — | — | 1 | 6.85 |
| CHEMBL4583393 | — | — | 1 | 6.84 |
| CHEMBL4584553 | — | — | 1 | 6.82 |
| CHEMBL4548828 | — | — | 1 | 6.78 |
| CHEMBL4448296 | — | — | 1 | 6.77 |
| CHEMBL4466230 | — | — | 1 | 6.76 |
| CHEMBL4483371 | — | — | 1 | 6.76 |
| CHEMBL4565144 | — | — | 1 | 6.58 |
| CHEMBL4160962 | — | — | 1 | 6.51 |
| CHEMBL4456880 | — | — | 1 | 6.22 |
| CHEMBL4455804 | — | — | 1 | 5.68 |
| CHEMBL4438198 | — | — | 1 | 5.54 |
| CHEMBL4524769 | — | — | 1 | 5.41 |
| CHEMBL4549903 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078685 | TOPIROXOSTAT | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4453043 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4455392 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4540231 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4444577 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4435696 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4438449 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4472263 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4444217 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4457729 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4530455 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4483545 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4522159 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4568537 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4583393 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4584553 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4548828 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL4448296 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4466230 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4483371 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4565144 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4160962 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4456880 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4455804 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4438198 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4524769 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4549903 | — | IC50 | = | 4590.0 | nM | 5.34 |