Assay Detail
Functional
CHEMBL4409386
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Antiproliferative activity against human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure based design, synthesis and in vitro antitumour activity of tiazofurin stereoisomers with nitrogen functions at the C-2' or C-3' positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 6.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.04 |
| CHEMBL4583780 | — | — | 1 | 5.99 |
| CHEMBL375197 | — | — | 1 | 5.42 |
| CHEMBL4452782 | — | — | 1 | 5.12 |
| CHEMBL219331 | — | — | 1 | 5.03 |
| CHEMBL4536894 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4583780 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL375197 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL4452782 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL219331 | — | IC50 | = | 9390.0 | nM | 5.03 |
| CHEMBL4536894 | — | IC50 | = | 12860.0 | nM | 4.89 |