Assay Detail
Functional
CHEMBL4409480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/Ned/378/05(H1N1)) infected in dog MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 13 | - | - |
| EC50 | 5 | 5.22 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.00 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.05 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.70 |
| CHEMBL4583652 | — | — | 1 | 4.12 |
| CHEMBL4465508 | — | — | 1 | - |
| CHEMBL4451587 | — | — | 1 | - |
| CHEMBL4457582 | — | — | 1 | - |
| CHEMBL4538303 | — | — | 1 | - |
| CHEMBL3299017 | — | — | 1 | - |
| CHEMBL4567127 | — | — | 1 | - |
| CHEMBL4475221 | — | — | 1 | - |
| CHEMBL4532325 | — | — | 1 | - |
| CHEMBL4518370 | — | — | 1 | - |
| CHEMBL4517740 | — | — | 1 | - |
| CHEMBL4582139 | — | — | 1 | - |
| CHEMBL4566092 | — | — | 1 | - |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | - |
| CHEMBL4470222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL660 | AMANTADINE | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4583652 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4465508 | — | Activity | - | — | - | |
| CHEMBL4451587 | — | Activity | - | — | - | |
| CHEMBL4457582 | — | Activity | - | — | - | |
| CHEMBL4538303 | — | Activity | - | — | - | |
| CHEMBL3299017 | — | Activity | - | — | - | |
| CHEMBL4567127 | — | Activity | - | — | - | |
| CHEMBL4475221 | — | Activity | - | — | - | |
| CHEMBL4532325 | — | Activity | - | — | - | |
| CHEMBL4518370 | — | Activity | - | — | - | |
| CHEMBL4517740 | — | Activity | - | — | - | |
| CHEMBL4582139 | — | Activity | - | — | - | |
| CHEMBL4566092 | — | Activity | - | — | - | |
| CHEMBL959 | RIMANTADINE | EC50 | > | 200000.0 | nM | - |
| CHEMBL4470222 | — | Activity | - | — | - |