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Assay Detail

CHEMBL4409481

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Influenza A virus (A/HK/7/87(H3N2)) infected in dog MDCK cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Influenza A virus
Confidence 1 — Organism
Curated By Autocuration

Target

Influenza A virus H3N2 (CHEMBL2366902)
Type ORGANISM
Organism Influenza A virus H3N2

Publication

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Macan AM, Harej A, Cazin I, Klobučar M, Stepanić V, Pavelić K, Pavelić SK, Schols D, Snoeck R, Andrei G, Raić-Malić S.
Eur J Med Chem (2019) 184 : 111739 -111739
PubMed 31586832 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 13 - -
EC50 5 6.22 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL959 RIMANTADINE 4.0 1 8.00
CHEMBL660 AMANTADINE 4.0 1 6.70
CHEMBL222813 ZANAMIVIR 4.0 1 6.40
CHEMBL1643 RIBAVIRIN 4.0 1 5.64
CHEMBL4583652 1 4.35
CHEMBL4465508 1 -
CHEMBL4451587 1 -
CHEMBL4457582 1 -
CHEMBL4538303 1 -
CHEMBL3299017 1 -
CHEMBL4567127 1 -
CHEMBL4475221 1 -
CHEMBL4532325 1 -
CHEMBL4518370 1 -
CHEMBL4517740 1 -
CHEMBL4582139 1 -
CHEMBL4566092 1 -
CHEMBL4470222 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL959 RIMANTADINE EC50 = 10.0 nM 8.00
CHEMBL660 AMANTADINE EC50 = 200.0 nM 6.70
CHEMBL222813 ZANAMIVIR EC50 = 400.0 nM 6.40
CHEMBL1643 RIBAVIRIN EC50 = 2300.0 nM 5.64
CHEMBL4583652 EC50 = 45000.0 nM 4.35
CHEMBL4465508 Activity - -
CHEMBL4451587 Activity - -
CHEMBL4457582 Activity - -
CHEMBL4538303 Activity - -
CHEMBL3299017 Activity - -
CHEMBL4567127 Activity - -
CHEMBL4475221 Activity - -
CHEMBL4532325 Activity - -
CHEMBL4518370 Activity - -
CHEMBL4517740 Activity - -
CHEMBL4582139 Activity - -
CHEMBL4566092 Activity - -
CHEMBL4470222 Activity - -