Assay Detail
Functional
CHEMBL4409489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Herpes simplex virus 2 G infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by microscopic analysis
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 13 | - | - |
| EC50 | 5 | 5.63 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.52 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.70 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.28 |
| CHEMBL3297805 | — | — | 1 | 5.03 |
| CHEMBL4465508 | — | — | 1 | - |
| CHEMBL4451587 | — | — | 1 | - |
| CHEMBL4457582 | — | — | 1 | - |
| CHEMBL4538303 | — | — | 1 | - |
| CHEMBL3299017 | — | — | 1 | - |
| CHEMBL4567127 | — | — | 1 | - |
| CHEMBL4475221 | — | — | 1 | - |
| CHEMBL4532325 | — | — | 1 | - |
| CHEMBL4518370 | — | — | 1 | - |
| CHEMBL4517740 | — | — | 1 | - |
| CHEMBL4582139 | — | — | 1 | - |
| CHEMBL4566092 | — | — | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL4470222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3297805 | — | EC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL4465508 | — | Activity | - | — | - | |
| CHEMBL4451587 | — | Activity | - | — | - | |
| CHEMBL4457582 | — | Activity | - | — | - | |
| CHEMBL4538303 | — | Activity | - | — | - | |
| CHEMBL3299017 | — | Activity | - | — | - | |
| CHEMBL4567127 | — | Activity | - | — | - | |
| CHEMBL4475221 | — | Activity | - | — | - | |
| CHEMBL4532325 | — | Activity | - | — | - | |
| CHEMBL4518370 | — | Activity | - | — | - | |
| CHEMBL4517740 | — | Activity | - | — | - | |
| CHEMBL4582139 | — | Activity | - | — | - | |
| CHEMBL4566092 | — | Activity | - | — | - | |
| CHEMBL31634 | BRIVUDINE | EC50 | > | 250000.0 | nM | - |
| CHEMBL4470222 | — | Activity | - | — | - |