Assay Detail
Binding
CHEMBL4409660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.36 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.70 |
| CHEMBL4574299 | — | — | 1 | 8.80 |
| CHEMBL4476294 | — | — | 1 | 8.80 |
| CHEMBL4544153 | — | — | 1 | 8.20 |
| CHEMBL4471208 | — | — | 1 | 8.08 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.02 |
| CHEMBL4543789 | — | — | 1 | 7.82 |
| CHEMBL4459410 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4574299 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4476294 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4544153 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4471208 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL2104993 | VORTIOXETINE | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL4543789 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4459410 | — | Ki | = | 38.0 | nM | 7.42 |