Assay Detail
Binding
CHEMBL4410467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.67 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4528475 | — | — | 1 | 8.82 |
| CHEMBL4060253 | — | — | 1 | 8.74 |
| CHEMBL4435891 | — | — | 1 | 8.68 |
| CHEMBL4577890 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4528475 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4060253 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4435891 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4577890 | — | IC50 | = | 3.8 | nM | 8.42 |