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Assay Detail

CHEMBL4410898

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SUDHL6 cells assessed as reduction in cell viability incubated for 4 days by celltiter glo luminescent assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SU-DHL-6
Confidence 1 — Organism
Curated By Autocuration

Target

SU-DHL-6 (CHEMBL4296496)
Type CELL-LINE
Organism Homo sapiens

Publication

INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ).
Yue EW, Li YL, Douty B, He C, Mei S, Wayland B, Maduskuie T, Falahatpisheh N, Sparks RB, Polam P, Zhu W, Glenn J, Feng H, Zhang K, Li Y, He X, Katiyar K, Covington M, Feldman P, Shin N, Wang KH, Diamond S, Li Y, Koblish HK, Hall L, Scherle P, Yeleswaram S, Xue CB, Metcalf B, Combs AP, Yao W.
ACS Med Chem Lett (2019) 10 : 1554 -1560
PubMed 31749910 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.54 9.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4574593 1 9.33
CHEMBL4297615 PARSACLISIB 3.0 1 8.80
CHEMBL4561896 1 8.68
CHEMBL4593387 1 8.62
CHEMBL4438376 1 8.51
CHEMBL4458634 1 8.13
CHEMBL4443149 1 7.89
CHEMBL4446120 1 7.85
CHEMBL2216863 DEZAPELISIB 2.0 1 7.75
CHEMBL4444112 1 7.68
CHEMBL4465303 1 7.36
CHEMBL4570334 1 7.22
CHEMBL4471294 1 7.14
CHEMBL4513857 1 7.00
CHEMBL4440146 1 6.85
CHEMBL4470672 1 6.77
CHEMBL4468580 1 6.08
CHEMBL4576207 1 5.89
CHEMBL4593849 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4574593 IC50 = 0.47 nM 9.33
CHEMBL4297615 PARSACLISIB IC50 = 1.6 nM 8.80
CHEMBL4561896 IC50 = 2.1 nM 8.68
CHEMBL4593387 IC50 = 2.4 nM 8.62
CHEMBL4438376 IC50 = 3.1 nM 8.51
CHEMBL4458634 IC50 = 7.4 nM 8.13
CHEMBL4443149 IC50 = 13.0 nM 7.89
CHEMBL4446120 IC50 = 14.0 nM 7.85
CHEMBL2216863 DEZAPELISIB IC50 = 18.0 nM 7.75
CHEMBL4444112 IC50 = 21.0 nM 7.68
CHEMBL4465303 IC50 = 44.0 nM 7.36
CHEMBL4570334 IC50 = 60.0 nM 7.22
CHEMBL4471294 IC50 = 73.0 nM 7.14
CHEMBL4513857 IC50 = 100.0 nM 7.00
CHEMBL4440146 IC50 = 140.0 nM 6.85
CHEMBL4470672 IC50 = 170.0 nM 6.77
CHEMBL4468580 IC50 = 840.0 nM 6.08
CHEMBL4576207 IC50 = 1300.0 nM 5.89
CHEMBL4593849 IC50 = 1800.0 nM 5.75