Assay Detail
Binding
CHEMBL4410951
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Inhibition of mTORC2 in human A431 cells assessed as AKT phosphorylation at S473 residue incubated for 3 hrs by HTRF assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.21 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564479 | — | — | 1 | 8.30 |
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 8.30 |
| CHEMBL4529672 | — | — | 1 | 7.96 |
| CHEMBL4549761 | — | — | 1 | 7.70 |
| CHEMBL4572049 | — | — | 1 | 7.70 |
| CHEMBL4588610 | — | — | 1 | 7.22 |
| CHEMBL4538004 | — | — | 1 | 7.10 |
| CHEMBL4538629 | — | — | 1 | 7.05 |
| CHEMBL4517253 | — | — | 1 | 7.05 |
| CHEMBL4585005 | — | — | 1 | 6.89 |
| CHEMBL4461815 | — | — | 1 | 6.85 |
| CHEMBL4441763 | — | — | 1 | 6.70 |
| CHEMBL4475845 | — | — | 1 | 6.70 |
| CHEMBL4456417 | — | — | 1 | 6.44 |
| CHEMBL4525459 | — | — | 1 | 6.17 |
| CHEMBL4440554 | — | — | 1 | - |
| CHEMBL4475002 | — | — | 1 | - |
| CHEMBL4451788 | — | — | 1 | - |
| CHEMBL4522109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564479 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3545097 | SAPANISERTIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4529672 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4549761 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4572049 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4588610 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4538004 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4538629 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4517253 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4585005 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4461815 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4441763 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4475845 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4456417 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4525459 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4440554 | — | IC50 | - | — | - | |
| CHEMBL4475002 | — | IC50 | - | — | - | |
| CHEMBL4451788 | — | IC50 | - | — | - | |
| CHEMBL4522109 | — | IC50 | - | — | - |